Friday, January 15, 2021
Our new paper talks about Spleen Tyrosine Kinase and signaling through interactions with integrins: PUB MED LINK and is titled Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk. This was collaboration between the University of Houston and the Texas Heart Institute.
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Thursday, October 22, 2020
Recent Seminar
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Friday, June 22, 2018
Magnetic Resonance Imaging of Atherosclerotic Plaque
Checkout our new paper:
Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1.PUBMED
https://www.ncbi.nlm.nih.gov/pubmed/29487319
Texas Heart Institute has developed a new technology that allows a cargo in a liposome to be selectively delivered to tissues expressing α4β1. This is important because plaques express this integrin and we are working on derivatives of this concept for other cargos and other integrins. Imagine therapeutics loaded in the liposome and brought at higher local concentration selectively to the plaques.
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https://www.ncbi.nlm.nih.gov/pubmed/29487319
Texas Heart Institute has developed a new technology that allows a cargo in a liposome to be selectively delivered to tissues expressing α4β1. This is important because plaques express this integrin and we are working on derivatives of this concept for other cargos and other integrins. Imagine therapeutics loaded in the liposome and brought at higher local concentration selectively to the plaques.
Wednesday, March 09, 2016
Docking
I am working on a number of docking projects. The exciting part is that I have a number of new students that are interested in working on the both the computational and wet lab validation of our predictions. We are refining the docking systems these will do NMR next week.
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Friday, October 09, 2015
Strasburg France
With the extra time on the last day we took the Munich -> Paris express train to Strasburg. The city was spectacular, with amazing little narrow streets and unique postcard shops.
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Tuesday, October 06, 2015
University of Stuttgart, Germany
I attended the “Simulating Soft and Active Matter with ESPResSo, ESPResSo++, and VOTCA” conference/workshop/developers meeting at the Institute for Computational Physics of the University of Stuttgart, Germany. Compiled supporting software libraries for both laptop and UH computation cluster. Those included: Boost, Cython, FFTW3, GSL, GROMAC, VOTCA, ESPRESSO, and ESPRESSO++. I also presented a poster developing: “Phosphorylation Mimicry in Espresso; Charge Gradients and Dynamics” at the conference.
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Thursday, January 15, 2015
49th US-Japan Conference on Cholera and Enteric Infections
This week has been a greatly enriching and learning experience at the 49th US-Japan Conference on Cholera. This conference integrates both basic science and field work, bringing a broad range of communities together to impact world health. I was deeply inspired by the stories from the teams coming back from Africa. Their commitment to interdict during a cholera outbreak is unwavering despite the logistic and security challenges in the field. Also a significant number of developments in vaccines and how they can be cost effectively targeted to vulnerable populations was encouraging. Each evening after the conference we were able to continue the networking over great central Florida fare, such as these at the Harries Seafood in downtown Gainsville.
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Tuesday, May 27, 2014
Cholera vs Enterotoxin
We are investigation the underlying mechanisms that cause Cholera to be significantly more deadly as compared to Enterotoxin despite the high level of commonality between the structures. A few amino acids variations in the A2 tail region leads to differential effects including the strength of domain-domain interactions and water access through a small gap in the A-domain to B-domain interface.
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Thursday, February 28, 2013
PTEN links to Marijuana Response
It is amazing that a small peptide can interfere with PTEN protein interactions with the Serotonin receptor. We have been exploring the interactions of that peptide with PTEN. We published in the Journal of Neuroscience on changes in activity in cells and looked at docking possible confirmations that were derived from Replicate Exchange Molecular Dynamics Simulations.
J Neurosci. 2013 Jan 23;33(4):1615-30
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J Neurosci. 2013 Jan 23;33(4):1615-30
Monday, October 24, 2011
PH domains in ROCK
We are looking at interactions of ROCK's catalytic domain and ROCK's PH domain. Interesting to look at a range of PH domains from many proteins. Here is a structural alignment done in VMD.
