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Tuesday, May 27, 2014

Cholera vs Enterotoxin 

We are investigation the underlying mechanisms that cause Cholera to be significantly more deadly as compared to Enterotoxin despite the high level of commonality between the structures. A few amino acids variations in the A2 tail region leads to differential effects including the strength of domain-domain interactions and water access through a small gap in the A-domain to B-domain interface.

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